| Sarah Michelle Gellar | Daphne Blake |
| Freddie Prinze Jr. | Fred Jones |
| Rowan Atkinson | Emile Mondavarious |
| Linda Cardellini | Velma Dinkley |
| Isla Fisher | Mary Jane |
| Steven Grives | N' Goo Tuana |
| Sam Greco | Zarkos |
| Matthew Lillard | Norville Rogers |
| Miguel A. Núñez Jr. | Voodoo Maestro |
| Neil Fanning | Scooby-Doo |
| Charles Stan Frazier | Himself |
| Craig Bullock | Himself |
| Director | Raja Gosnell |
| Producer | Charles Roven; Joseph Barbera; Sheryl Benko; Richard Suckle |
| Writer | Joseph Barbera; Craig Titley; William Hanna; James Gunn |
| Cinematography | David Eggby |
| Musician | David Newman |
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| Additional Scenes Commentary by Freddie Prinze, Jr., Sarah Michelle Gellar, Matthew Lillard, Linda Cardellini and Rowan Atkinson Commentary by Director Raja Gosnell, Screenwriter James Gunn and Producers Charles Roven and Richard Suckle Unmasking The Mystery Behind Scooby-Doo Scary Places: Production Design The Mystery Van Daphne Fight Scene Rain on the Set Outkast "Land Of a Million Drums" Music Video Theatrical Trailer |