| Jake Gyllenhaal | Robert Graysmith |
| Mark Ruffalo | Inspector David Toschi |
| Anthony Edwards | Inspector William Armstrong |
| Robert Downey Jr. | Paul Avery |
| Brian Cox | Melvin Belli |
| John Carroll Lynch | Arthur Leigh Allen |
| Richmond Arquette | Zodiac 1 & 2 |
| Bob Stephenson | Zodiac 3 |
| John Lacy | Zodiac 4 |
| Chloë Sevigny | Melanie |
| Elias Koteas | |
| Chloe Sevigny |
| Director | David Fincher; Alexander Bulkley |
| Producer | Mike Medavoy; Cean Chaffin; Ceán Chaffin; Brad Fischer |
| Writer | James Vanderbilt; Robert Graysmith |
| Cinematography | Harris Savides |
| Musician | David Shire |
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| Disc 1: | Commentary by Director David Fincher Commentary by Jake Gyllenhaal, Robert Downey Jr., Brad Fischer, James Vanderbilt and James Ellroy Zodiac Deciphered: An Exhaustive Behind-the-Scenes Documentary on the Making of Zodiac The Visual Effects of Zodiac Previsualization: Split-Screen Comparisons Between Animatics and Finished Film for the Three Murder Sequences This Is The Zodiac Speaking: An All-New, Feature-Length Documentary (Produced and Directed by David Prior) Covering Every Aspect of the Investigation, Including New Interviews with the Original Investigators and Surviving Victims His Name Was Arthur Leigh Allen: The Truth About the Prime Suspect in the Zodiac Case from People Who Knew Him and the Police Who Investigated Him. |